Inositol monophosphatase 2

IMPA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2, inositol monophosphatase 2
External IDs	OMIM: 605922; MGI: 2149728; HomoloGene: 22799; GeneCards: IMPA2; OMA:IMPA2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	12,030,877 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; skin of abdomen; ; gastrocnemius muscle; ; skin of leg; ; muscle of thigh; ; human kidney; ; vulva; ; skin of thigh; ; Skeletal muscle tissue of rectus abdominis; ; mucosa of transverse colon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	inositol monophosphate 1-phosphatase activity; inositol monophosphate phosphatase activity; hydrolase activity; protein binding; protein homodimerization activity; metal ion binding; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity;
Cellular component	cytoplasm; cytosol;
Biological process	phosphate-containing compound metabolic process; phosphatidylinositol phosphate biosynthetic process; inositol phosphate metabolic process; inositol metabolic process; inositol biosynthetic process; signal transduction; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3613
	114663
	ENSG00000141401
	n/a
	O14732
	Q91UZ5
	NM_014214
	NM_053261
	NP_055029
	NP_444491
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.