INF2

INF2
Identifiers
Aliases	INF2, C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, inverted formin, FH2 and WH2 domain containing, inverted formin 2
External IDs	OMIM: 610982; MGI: 1917685; HomoloGene: 82406; GeneCards: INF2; OMA:INF2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	104,722,535 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	112,615,557 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; C1 segment; ; mucosa of transverse colon; ; right coronary artery; ; gastric mucosa; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; putamen; ; right frontal lobe;
	Top expressed in
	gastrula; ; superior frontal gyrus; ; olfactory tubercle; ; decidua; ; nucleus accumbens; ; stroma of bone marrow; ; primary visual cortex; ; epithelium of lens; ; transitional epithelium of urinary bladder; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm;
Biological process	regulation of mitochondrial fission; actin cytoskeleton organization; cellular component organization;
	Sources:Amigo / QuickGO
Orthologs
	64423
	70435
	ENSG00000203485
	ENSMUSG00000037679
	Q27J81
	Q0GNC1
	NM_001031714; NM_022489; NM_032714
	NM_198411
	NP_001026884; NP_071934; NP_116103
	NP_940803; NP_001361128
	Wikidata
View/Edit Human	View/Edit Mouse

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene. It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi. INF2 plays a role in mitochondrial fission and dorsal stress fiber formation. INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates disassembly of actin through encircling and severing filaments.