ING5

ING5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C6W
Identifiers
Aliases	ING5, p28inhibitor of growth family member 5
External IDs	OMIM: 608525; MGI: 1922816; HomoloGene: 90955; GeneCards: ING5; OMA:ING5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,729,478 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,749,823 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right uterine tube; ; left ovary; ; right hemisphere of cerebellum; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right ovary; ; pituitary gland; ; anterior pituitary;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; otic vesicle; ; otolith organ; ; hand; ; utricle; ; cumulus cell; ; retinal pigment epithelium; ; ciliary body; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	methylated histone binding; protein binding; metal ion binding; chromatin binding;
Cellular component	MOZ/MORF histone acetyltransferase complex; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; DNA replication; negative regulation of growth; regulation of transcription, DNA-templated; histone acetylation; histone H3 acetylation; transcription, DNA-templated; protein acetylation; negative regulation of cell population proliferation; positive regulation of apoptotic process; regulation of signal transduction by p53 class mediator; chromatin organization; positive regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84289
	66262
	ENSG00000168395
	ENSMUSG00000026283
	Q8WYH8
	Q9D8Y8
	NM_032329; NM_001330161; NM_001330162
	NM_025454; NM_029340
	NP_001317090; NP_001317091; NP_115705
	NP_079730
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.