INPP1

INPP1
Identifiers
Aliases	INPP1, inositol polyphosphate-1-phosphatase
External IDs	OMIM: 147263; MGI: 104848; HomoloGene: 1655; GeneCards: INPP1; OMA:INPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	190,371,665 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,856,847 bp
RNA expression pattern
	Top expressed in
	sperm; ; corpus callosum; ; middle frontal gyrus; ; mucosa of pharynx; ; cervix epithelium; ; inferior ganglion of vagus nerve; ; left testis; ; epithelium of nasopharynx; ; right testis; ; duodenum;
	Top expressed in
	granulocyte; ; neural layer of retina; ; cerebellar cortex; ; thymus; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; seminal vesicula; ; superior frontal gyrus; ; lobe of cerebellum; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-1,4-bisphosphate 1-phosphatase activity; inositol-1,3,4-trisphosphate 1-phosphatase activity; hydrolase activity; metal ion binding; protein binding;
Cellular component	cytosol;
Biological process	phosphate-containing compound metabolic process; phosphatidylinositol phosphate biosynthetic process; inositol phosphate metabolic process; signal transduction; dephosphorylation; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3628
	16329
	ENSG00000151689
	ENSMUSG00000026102
	P49441
	P49442
	NM_001128928; NM_002194
	NM_008384
	NP_001122400; NP_002185
	NP_032410
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.