INPP5A

INPP5A
Identifiers
Aliases	INPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs	OMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	132,783,480 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,159,568 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; saphenous vein; ; myocardium of left ventricle; ; middle temporal gyrus; ; popliteal artery; ; tibial arteries; ; sperm; ; external globus pallidus; ; right ventricle; ; gastric mucosa;
	Top expressed in
	Ileal epithelium; ; cardiac muscle tissue of left ventricle; ; lobe of cerebellum; ; right ventricle; ; cerebellar vermis; ; interventricular septum; ; plantaris muscle; ; ascending aorta; ; extensor digitorum longus muscle; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PH domain binding; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; protein binding; hydrolase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity;
Cellular component	plasma membrane; membrane; intracellular anatomical structure;
Biological process	inositol phosphate metabolic process; phosphatidylinositol dephosphorylation; inositol phosphate-mediated signaling; inositol phosphate dephosphorylation; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3632
	212111
	ENSG00000068383
	ENSMUSG00000025477
	Q14642; Q5T1B3
	Q7TNC9
	NM_005539; NM_001321042
	NM_001127363; NM_183144; NM_001355162
	NP_001307971; NP_005530
	NP_001120835; NP_001342091; NP_898967
	Wikidata
View/Edit Human	View/Edit Mouse

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins (1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.