INPP5B

INPP5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTC, 3N9V, 4CML, 5A7J, 5A7I
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	OMIM: 147264; MGI: 103257; HomoloGene: 69021; GeneCards: INPP5B; OMA:INPP5B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,947,057 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,695,304 bp
RNA expression pattern
	Top expressed in
	left ovary; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; right ovary; ; ascending aorta; ; granulocyte; ; left coronary artery; ; cerebellar hemisphere;
	Top expressed in
	right lung lobe; ; neural layer of retina; ; left lung; ; right kidney; ; proximal tubule; ; human kidney; ; granulocyte; ; lobe of cerebellum; ; cerebellar vermis; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding; hydrolase activity; GTPase activator activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol phosphate phosphatase activity;
Cellular component	integral component of membrane; cytosol; endosome; phagocytic vesicle membrane; Golgi apparatus; early endosome membrane; membrane; plasma membrane; cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; cytoplasm;
Biological process	flagellated sperm motility; in utero embryonic development; inositol phosphate metabolic process; regulation of protein processing; phosphatidylinositol dephosphorylation; spermatogenesis; regulation of small GTPase mediated signal transduction; signal transduction; positive regulation of GTPase activity; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3633
	16330
	ENSG00000204084
	ENSMUSG00000028894
	P32019
	Q8K337
	NM_001297434; NM_005540; NM_001350227; NM_001350228
	NM_008385
NP_001284363; NP_005531; NP_001337156; NP_001337157; NP_001352749;
	NP_001352750; NP_001352751; NP_001352752; NP_001352753; NP_001352754
	NP_032411
	Wikidata
View/Edit Human	View/Edit Mouse

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.