INPP5D

INPP5D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSX
Identifiers
Aliases	INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship, inositol polyphosphate-5-phosphatase D
External IDs	OMIM: 601582; MGI: 107357; HomoloGene: 4046; GeneCards: INPP5D; OMA:INPP5D - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,207,903 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,648,229 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; monocyte; ; bone marrow; ; bone marrow cells; ; appendix; ; tonsil; ; sural nerve;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; blood; ; spleen; ; mesenteric lymph nodes; ; thymus; ; tibiofemoral joint; ; submandibular gland; ; fetal liver hematopoietic progenitor cell; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; inositol-polyphosphate 5-phosphatase activity; PTB domain binding; phosphatidylinositol trisphosphate phosphatase activity; protein binding; hydrolase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;
Cellular component	cytoplasm; membrane; plasma membrane; membrane raft; cytoskeleton; cytosol;
Biological process	negative regulation of monocyte differentiation; intracellular signal transduction; determination of adult lifespan; positive regulation of erythrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of granulocyte differentiation; immune system process; positive regulation of B cell differentiation; negative regulation of B cell activation; inositol phosphate metabolic process; negative regulation of neutrophil differentiation; negative regulation of immune response; phosphatidylinositol dephosphorylation; positive regulation of lymphocyte differentiation; immunoglobulin mediated immune response; positive regulation of apoptotic process; phosphate-containing compound metabolic process; phosphatidylinositol biosynthetic process; negative regulation of signal transduction; negative regulation of B cell proliferation; T cell receptor signaling pathway; leukocyte migration; signal transduction; negative regulation of bone resorption; negative regulation of cell population proliferation; apoptotic process; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3635
	16331
	ENSG00000168918; ENSG00000281614
	ENSMUSG00000026288
	Q92835
	Q9ES52
	NM_001017915; NM_005541
	NM_001110192; NM_001110193; NM_010566
	NP_001017915; NP_005532
	NP_001103662; NP_001103663; NP_034696
	Wikidata
View/Edit Human	View/Edit Mouse

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.