INPPL1

INPPL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K4P, 2KSO, 2MK2, 3NR8, 4A9C
Identifiers
Aliases	INPPL1, OPSMD, SHIP2, inositol polyphosphate phosphatase like 1
External IDs	OMIM: 600829; MGI: 1333787; HomoloGene: 1204; GeneCards: INPPL1; OMA:INPPL1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,239,105 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,487,436 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; muscle layer of sigmoid colon; ; left lobe of thyroid gland; ; right uterine tube; ; right ovary; ; granulocyte; ; left uterine tube; ; apex of heart;
	Top expressed in
	muscle of thigh; ; digastric muscle; ; extraocular muscle; ; Ileal epithelium; ; internal carotid artery; ; ventricular zone; ; lactiferous gland; ; cardiac muscle tissue of left ventricle; ; temporal muscle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; SH2 domain binding; protein binding; actin binding; hydrolase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;
Cellular component	Golgi apparatus; cell projection; membrane; filopodium; plasma membrane; cytoskeleton; lamellipodium; cytoplasm; cytosol;
Biological process	endocytosis; cellular lipid metabolic process; actin filament organization; immune system process; inositol phosphate metabolic process; endochondral ossification; post-embryonic development; negative regulation of gene expression; response to insulin; cell adhesion; phosphatidylinositol dephosphorylation; glucose metabolic process; phosphatidylinositol biosynthetic process; ruffle assembly; negative regulation of cell population proliferation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3636
	16332
	ENSG00000165458
	ENSMUSG00000032737
	O15357
	Q6P549
	NM_001567
	NM_001122739; NM_010567
	NP_001558
	NP_001116211; NP_034697
	Wikidata
View/Edit Human	View/Edit Mouse

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.