Insulin-induced gene 1 protein

INSIG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J81
Identifiers
Aliases	INSIG1, CL-6, CL6, insulin induced gene 1
External IDs	OMIM: 602055; MGI: 1916289; HomoloGene: 4047; GeneCards: INSIG1; OMA:INSIG1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	155,310,235 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	28,283,660 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; right lobe of liver; ; skin of thigh; ; Epithelium of choroid plexus; ; superior vestibular nucleus; ; mucosa of paranasal sinus; ; retinal pigment epithelium; ; islet of Langerhans; ; secondary oocyte; ; tibia;
	Top expressed in
	epithelium of small intestine; ; secondary oocyte; ; migratory enteric neural crest cell; ; ciliary body; ; left lobe of liver; ; parotid gland; ; olfactory epithelium; ; submandibular gland; ; genital tubercle; ; cumulus cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; SREBP-SCAP-Insig complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	roof of mouth development; steroid metabolic process; negative regulation of fat cell differentiation; sterol biosynthetic process; negative regulation of fatty acid biosynthetic process; lipid metabolism; cholesterol metabolic process; response to sterol depletion; cranial suture morphogenesis; negative regulation of cargo loading into COPII-coated vesicle; inner ear morphogenesis; middle ear morphogenesis; SREBP signaling pathway; cholesterol biosynthetic process; cell population proliferation; triglyceride metabolic process; negative regulation of steroid biosynthetic process; cellular response to sterol; SREBP-SCAP complex retention in endoplasmic reticulum; cholesterol homeostasis; negative regulation of protein exit from endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
	3638
	231070
	ENSG00000186480
	ENSMUSG00000045294
	O15503
	Q8BGI3
NM_001346590; NM_001346591; NM_001346592; NM_001346593; NM_001346594;
	NM_005542; NM_198336; NM_198337
	NM_153526
NP_001333519; NP_001333520; NP_001333521; NP_001333522; NP_001333523;
	NP_005533; NP_938150; NP_938151
	NP_705746
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene.

INSIG1 is short for insulin-induced gene 1; it is located on chromosome 7 (7q36). This human gene encodes for a transmembrane protein of 277 amino acids with probably 6 transmembrane domains. It is localized in the endoplasmic reticulum (ER) and seems to be expressed in all tissues, especially in liver. This gene is called an insulin-induced gene because the molecule insulin can regulate it. Importantly, the protein encoded by this gene plays a critical role in regulating cholesterol concentrations in cells.