INSIG2

INSIG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J82
Identifiers
Aliases	INSIG2, INSIG-2, insulin induced gene 2
External IDs	OMIM: 608660; MGI: 1920249; HomoloGene: 9400; GeneCards: INSIG2; OMA:INSIG2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	118,110,997 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	121,260,318 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; right lobe of liver; ; body of pancreas; ; islet of Langerhans; ; tibia; ; tibial arteries; ; left coronary artery; ; ascending aorta; ; cartilage tissue; ; Descending thoracic aorta;
	Top expressed in
	interventricular septum; ; left lobe of liver; ; iris; ; ciliary body; ; retinal pigment epithelium; ; Epithelium of choroid plexus; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; skin of external ear; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; protein binding;
Cellular component	integral component of membrane; SREBP-SCAP-Insig complex; membrane; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	roof of mouth development; steroid metabolic process; response to fatty acid; sterol biosynthetic process; negative regulation of fatty acid biosynthetic process; lipid metabolism; cholesterol metabolic process; response to sterol depletion; cranial suture morphogenesis; response to insulin; response to lipid; inner ear morphogenesis; middle ear morphogenesis; SREBP signaling pathway; cholesterol biosynthetic process; triglyceride metabolic process; negative regulation of steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51141
	72999
	ENSG00000125629
	ENSMUSG00000003721
	Q9Y5U4
	Q91WG1
NM_016133; NM_001321329; NM_001321330; NM_001321331; NM_001321332;
	NM_001321333
	NM_001271531; NM_001271532; NM_133748; NM_178082; NM_001357251
NP_001308258; NP_001308259; NP_001308260; NP_001308261; NP_001308262;
	NP_057217
	NP_001258460; NP_001258461; NP_598509; NP_835183; NP_001344180
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the INSIG2 gene.