INTS12

INTS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEV
Identifiers
Aliases	INTS12, INT12, PHF22, SBBI22, integrator complex subunit 12
External IDs	OMIM: 611355; MGI: 1919043; HomoloGene: 32474; GeneCards: INTS12; OMA:INTS12 - orthologs
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	132,816,749 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; right ventricle; ; islet of Langerhans; ; gastrocnemius muscle; ; jejunal mucosa; ; triceps brachii muscle; ; ganglionic eminence; ; biceps brachii; ; Achilles tendon;
	Top expressed in
	secondary oocyte; ; genital tubercle; ; zygote; ; primary oocyte; ; tail of embryo; ; granulocyte; ; otic placode; ; medial ganglionic eminence; ; epiblast; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	integrator complex; nucleoplasm; nucleus;
Biological process	snRNA processing; snRNA transcription by RNA polymerase II; snRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	57117
	71793
	n/a
	ENSMUSG00000028016
	Q96CB8
	Q9D168
	NM_001142471; NM_020395
	NM_027927
	NP_001135943; NP_065128; NP_001135943.1; NP_065128.2
	NP_082203
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a protein that in humans is encoded by the INTS12 gene.

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1) and U2 (RNU2)