IQGAP1

IQGAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X0H, 2RR8, 3FAY, 3I6X
Identifiers
Aliases	IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1
External IDs	OMIM: 603379; MGI: 1352757; HomoloGene: 74514; GeneCards: IQGAP1; OMA:IQGAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,502,239 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,475,722 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; monocyte; ; skin of hip; ; skin of thigh; ; right coronary artery; ; body of uterus; ; secondary oocyte; ; Descending thoracic aorta; ; lower lobe of lung;
	Top expressed in
	left lung lobe; ; right lung lobe; ; left colon; ; stria vascularis; ; tibiofemoral joint; ; vestibular membrane of cochlear duct; ; corneal stroma; ; granulocyte; ; conjunctival fornix; ; carotid body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; S100 protein binding; protein domain specific binding; protein-containing complex binding; protein serine/threonine kinase activator activity; GTPase inhibitor activity; protein binding; protein phosphatase binding; protein kinase binding; phosphatidylinositol-3,4,5-trisphosphate binding; GTPase activator activity; mitogen-activated protein kinase binding; cadherin binding; calmodulin binding; small GTPase binding; molecular adaptor activity;
Cellular component	cytoplasm; cytosol; lateral plasma membrane; cell-cell junction; membrane; microtubule cytoskeleton; growth cone; ruffle; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; slit diaphragm; axon; midbody; cell leading edge; actin filament; actin cytoskeleton; neuron projection; cytoplasmic ribonucleoprotein granule; microtubule; extracellular exosome; membrane raft; nucleus; focal adhesion; secretory granule membrane; protein-containing complex; ribonucleoprotein complex;
Biological process	cellular response to calcium ion; glomerular visceral epithelial cell development; epidermal growth factor receptor signaling pathway; negative regulation of dephosphorylation; regulation of GTPase activity; cellular response to platelet-derived growth factor stimulus; cellular response to fibroblast growth factor stimulus; neuron projection extension; cellular response to epidermal growth factor stimulus; regulation of cytokine production; fibroblast growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; signal transduction; positive regulation of protein kinase activity; positive regulation of focal adhesion assembly; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of GTPase activity; positive regulation of protein localization; positive regulation of dendrite development; positive regulation of MAP kinase activity; positive regulation of vascular associated smooth muscle cell migration; negative regulation of GTPase activity; response to angiotensin; neutrophil degranulation; regulation of mitotic cell cycle; cell migration; viral process;
	Sources:Amigo / QuickGO
Orthologs
	8826
	29875
	ENSG00000140575
	ENSMUSG00000030536
	P46940
	Q9JKF1
	NM_003870
	NM_016721
	NP_003861
	NP_057930
	Wikidata
View/Edit Human	View/Edit Mouse

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.