IRAK3

IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	66,254,622 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	120,038,035 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow; ; parietal pleura; ; blood; ; right lung; ; bone marrow cells; ; palpebral conjunctiva; ; spleen; ; lower lobe of lung; ; trabecular bone;
	Top expressed in
	granulocyte; ; gastrula; ; spermatocyte; ; seminiferous tubule; ; spermatid; ; bone marrow; ; ankle; ; sciatic nerve; ; lip; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; transferase activity; magnesium ion binding; protein serine/threonine kinase activity; kinase activity; protein homodimerization activity; protein heterodimerization activity; ATP binding; protein binding;
Cellular component	cytoplasm; nucleus; plasma membrane;
Biological process	response to lipopolysaccharide; negative regulation of innate immune response; signal transduction; negative regulation of macrophage cytokine production; protein autophosphorylation; negative regulation of protein-containing complex disassembly; response to interleukin-1; response to exogenous dsRNA; protein phosphorylation; negative regulation of toll-like receptor signaling pathway; cytokine-mediated signaling pathway; response to virus; response to peptidoglycan; negative regulation of cytokine-mediated signaling pathway; regulation of protein-containing complex disassembly; positive regulation of macrophage tolerance induction; negative regulation of NF-kappaB transcription factor activity; phosphorylation; negative regulation of protein catabolic process; negative regulation of interleukin-6 production; interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; negative regulation of MAP kinase activity; negative regulation of tumor necrosis factor production; negative regulation of interleukin-12 production; MyD88-dependent toll-like receptor signaling pathway; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11213
	73914
	ENSG00000090376
	ENSMUSG00000020227
	Q9Y616
	Q8K4B2
	NM_007199; NM_001142523
	NM_028679; NM_001359184
	NP_001135995; NP_009130
	NP_082955; NP_001346113
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene. Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.