IRF1

IRF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IF1
Identifiers
Aliases	IRF1, IRF-1, MAR, interferon regulatory factor 1
External IDs	OMIM: 147575; MGI: 96590; HomoloGene: 1658; GeneCards: IRF1; OMA:IRF1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,669,200 bp
RNA expression pattern
	n/a
	Top expressed in
	granulocyte; ; jejunum; ; mesenteric lymph nodes; ; duodenum; ; corneal stroma; ; large intestine; ; spleen; ; colon; ; ileum; ; primary oocyte;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleus;
Biological process	apoptotic process; regulation of CD8-positive, alpha-beta T cell proliferation; CD8-positive, alpha-beta T cell differentiation; regulation of innate immune response; negative regulation of regulatory T cell differentiation; regulation of transcription, DNA-templated; cellular response to interferon-beta; interferon-gamma-mediated signaling pathway; immune system process; regulation of adaptive immune response; blood coagulation; regulation of MyD88-dependent toll-like receptor signaling pathway; transcription by RNA polymerase II; transcription, DNA-templated; regulation of cell cycle; positive regulation of transcription, DNA-templated; cellular response to mechanical stimulus; defense response to virus; type I interferon signaling pathway; regulation of immune response; regulation of gene expression; innate immune response; negative regulation of transcription, DNA-templated; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; positive regulation of interferon-beta production;
	Sources:Amigo / QuickGO
Orthologs
	3659
	16362
	ENSG00000125347
	ENSMUSG00000018899
	P10914
	P15314
	NM_002198
	NM_001159393; NM_001159396; NM_008390
	NP_002189; NP_001341853; NP_001341854
	NP_001152865; NP_001152868; NP_032416
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.