IRF5

IRF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DSH
Identifiers
Aliases	IRF5, SLEB10, interferon regulatory factor 5
External IDs	OMIM: 607218; MGI: 1350924; HomoloGene: 8088; GeneCards: IRF5; OMA:IRF5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,950,038 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,541,870 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; blood; ; bone marrow cells; ; lymph node; ; upper lobe of left lung; ; testicle; ; right uterine tube; ; right coronary artery;
	Top expressed in
	mesenteric lymph nodes; ; stroma of bone marrow; ; granulocyte; ; spleen; ; lip; ; right kidney; ; female urethra; ; proximal tubule; ; esophagus; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of interleukin-12 production; interferon-gamma-mediated signaling pathway; immune system process; regulation of transcription by RNA polymerase II; positive regulation of interferon-alpha production; response to muramyl dipeptide; transcription, DNA-templated; defense response to virus; type I interferon signaling pathway; response to peptidoglycan; positive regulation of apoptotic process; innate immune response; positive regulation of transcription by RNA polymerase II; positive regulation of interferon-beta production; cytokine-mediated signaling pathway; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3663
	27056
	ENSG00000128604
	ENSMUSG00000029771
	Q13568
	P56477
NM_001098627; NM_001098629; NM_001098630; NM_001242452; NM_032643;
	NM_001347928; NM_001364314
	NM_001252382; NM_012057; NM_001311083
NP_001092097; NP_001092099; NP_001092100; NP_001229381; NP_116032;
	NP_001334857; NP_001351243; NP_001092099.1
	NP_001239311; NP_001298012; NP_036187
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.