IRF8

IRF8
Identifiers
Aliases	IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8
External IDs	OMIM: 601565; MGI: 96395; HomoloGene: 1629; GeneCards: IRF8; OMA:IRF8 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	85,922,606 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,483,433 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lymph node; ; spleen; ; secondary oocyte; ; appendix; ; granulocyte; ; blood; ; epithelium of colon; ; bone marrow; ; rectum;
	Top expressed in
	Ileal epithelium; ; mesenteric lymph nodes; ; spleen; ; bone marrow; ; tibiofemoral joint; ; submandibular gland; ; crypt of lieberkuhn of small intestine; ; jejunum; ; stroma of bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	myeloid cell differentiation; regulation of transcription, DNA-templated; response to bacterium; positive regulation of interleukin-12 production; interferon-gamma-mediated signaling pathway; positive regulation of interferon-gamma production; positive regulation of transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; positive regulation of transcription, DNA-templated; defense response to bacterium; type I interferon signaling pathway; immune response; phagocytosis; cellular response to lipopolysaccharide; defense response to protozoan; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; cellular response to interferon-gamma; autophagy; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3394
	15900
	ENSG00000140968
	ENSMUSG00000041515
	Q02556
	P23611
	NM_002163; NM_001363907; NM_001363908
	NM_001301811; NM_008320
	NP_002154; NP_001350836; NP_001350837
	NP_001288740; NP_032346
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.