IRX1

IRX1
Identifiers
Aliases	IRX1, IRX-5, IRXA1, iroquois homeobox 1
External IDs	OMIM: 606197; MGI: 1197515; HomoloGene: 19065; GeneCards: IRX1; OMA:IRX1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	3,601,403 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	72,111,842 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; epithelium of lactiferous gland; ; lactiferous duct; ; renal medulla; ; skin of arm; ; minor salivary glands; ; gonad; ; human kidney; ; skin of leg; ; subcutaneous adipose tissue;
	Top expressed in
	vestibular membrane of cochlear duct; ; digit; ; right lung; ; left lung; ; parotid gland; ; right lung lobe; ; incisor; ; otic placode; ; interventricular septum; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	specification of loop of Henle identity; metanephros development; regulation of transcription, DNA-templated; proximal/distal pattern formation involved in metanephric nephron development; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	79192
	16371
	ENSG00000170549
	ENSMUSG00000060969
	P78414
	P81068
	NM_024337
	NM_010573
	NP_077313
	NP_034703
	Wikidata
View/Edit Human	View/Edit Mouse

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning. IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.