ITGB1BP1

ITGB1BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DX8, 4DX9, 4JIF
Identifiers
Aliases	ITGB1BP1, ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B, integrin subunit beta 1 binding protein 1
External IDs	OMIM: 607153; MGI: 1306802; HomoloGene: 3496; GeneCards: ITGB1BP1; OMA:ITGB1BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	9,423,528 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	21,336,285 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; subcutaneous adipose tissue; ; abdominal fat; ; tibial nerve; ; right frontal lobe; ; caudate nucleus; ; putamen; ; gastric mucosa; ; apex of heart; ; C1 segment;
	Top expressed in
	seminiferous tubule; ; spermatid; ; cerebellar cortex; ; white adipose tissue; ; lobe of cerebellum; ; cerebellar vermis; ; morula; ; nucleus accumbens; ; olfactory tubercle; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	integrin binding; kinase binding; protein binding; GDP-dissociation inhibitor activity; protein kinase binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; focal adhesion; ruffle; plasma membrane; perinuclear region of cytoplasm; cytoskeleton; nucleus; lamellipodium; cell periphery; nucleoplasm; microtubule organizing center; nuclear body;
Biological process	Notch signaling pathway; positive regulation of protein targeting to membrane; cell differentiation; activation of protein kinase B activity; myoblast migration; negative regulation of fibroblast migration; regulation of cell adhesion mediated by integrin; intracellular signal transduction; positive regulation of protein kinase B signaling; regulation of transcription, DNA-templated; negative regulation of protein kinase activity; regulation of GTPase activity; biomineral tissue development; negative regulation of protein binding; cellular response to fibroblast growth factor stimulus; receptor clustering; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; transcription, DNA-templated; positive regulation of endothelial cell migration; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of protein targeting to membrane; tube formation; regulation of integrin-mediated signaling pathway; cell adhesion; angiogenesis; positive regulation of cell population proliferation; protein transport; integrin-mediated signaling pathway; negative regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; cellular response to vascular endothelial growth factor stimulus; integrin activation; cell-matrix adhesion; negative regulation of substrate adhesion-dependent cell spreading; cell migration; negative regulation of focal adhesion assembly; positive regulation of cell division; positive regulation of stress fiber assembly; positive regulation of Notch signaling pathway; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9270
	16413
	ENSG00000119185
	ENSMUSG00000062352
	O14713
	O35671
NM_004763; NM_022334; NM_001319066; NM_001319067; NM_001319068;
	NM_001319069; NM_001319070; NM_001369744; NM_001369745; NM_001369746; NM_001369747; NM_001369748; NM_001369749; NM_001369750
	NM_008403; NM_001355609
NP_001305995; NP_001305996; NP_001305997; NP_001305998; NP_001305999;
	NP_004754; NP_071729; NP_001356673; NP_001356674; NP_001356675; NP_001356676; NP_001356677; NP_001356678; NP_001356679
	NP_032429; NP_001342538
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.