ITIH2

ITIH2
Identifiers
Aliases	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDs	OMIM: 146640; MGI: 96619; HomoloGene: 1668; GeneCards: ITIH2; OMA:ITIH2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	7,749,520 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	10,136,207 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; testicle; ; Epithelium of choroid plexus; ; tibialis anterior muscle; ; cerebellar hemisphere; ; putamen; ; right hemisphere of cerebellum; ; prefrontal cortex; ; pancreatic ductal cell;
	Top expressed in
	left lobe of liver; ; gallbladder; ; fetal liver hematopoietic progenitor cell; ; human fetus; ; vestibular membrane of cochlear duct; ; ankle joint; ; abdominal wall; ; sexually immature organism; ; ascending aorta; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	blood microparticle; extracellular exosome; extracellular region; endoplasmic reticulum lumen; collagen-containing extracellular matrix;
Biological process	hyaluronan metabolic process; negative regulation of peptidase activity; negative regulation of endopeptidase activity; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3698
	16425
	ENSG00000151655
	ENSMUSG00000037254
	P19823
	Q61703
	NM_002216
	NM_010582
	NP_002207
	NP_034712
	Wikidata
View/Edit Human	View/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.