ITPR2

ITPR2
Identifiers
Aliases	ITPR2, CFAP48, IP3R2, ANHD, INSP3R2, inositol 1,4,5-trisphosphate receptor type 2
External IDs	OMIM: 600144; MGI: 99418; HomoloGene: 37593; GeneCards: ITPR2; OMA:ITPR2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	26,833,194 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	146,403,721 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; germinal epithelium; ; skin of thigh; ; epithelium of colon; ; skin of hip; ; sural nerve; ; liver; ; oral cavity; ; bone marrow cells; ; lactiferous duct;
	Top expressed in
	Ileal epithelium; ; zygote; ; oocyte; ; primary oocyte; ; secondary oocyte; ; corneal stroma; ; thymus; ; blood; ; ankle joint; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; calcium-release channel activity; calcium ion transmembrane transporter activity; ion channel activity; calcium ion binding; phosphatidylinositol binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; scaffold protein binding; inositol 1,4,5 trisphosphate binding;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; receptor complex; plasma membrane; sarcoplasmic reticulum; cell cortex; platelet dense tubular network membrane; sarcoplasmic reticulum membrane; nucleus; endoplasmic reticulum; cytoplasmic vesicle membrane; secretory granule membrane;
Biological process	regulation of cardiac conduction; response to hypoxia; cellular response to ethanol; regulation of insulin secretion; ion transport; platelet activation; calcium ion transmembrane transport; transmembrane transport; inositol phosphate-mediated signaling; cellular response to cAMP; signal transduction; calcium ion transport; release of sequestered calcium ion into cytosol; transport;
	Sources:Amigo / QuickGO
Orthologs
	3709
	16439
	ENSG00000123104
	ENSMUSG00000030287
	Q14571
	Q9Z329
	NM_002223
	NM_010586; NM_019923
	NP_002214
	NP_034716; NP_064307
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.