Intersectin 1

ITSN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KI1, 2KGR, 2KHN, 3QBV, 4IIM
Identifiers
Aliases	ITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
External IDs	OMIM: 602442; MGI: 1338069; HomoloGene: 2277; GeneCards: ITSN1; OMA:ITSN1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,899,861 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,717,485 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tibia; ; saphenous vein; ; parietal pleura; ; optic nerve; ; adipose tissue; ; pericardium; ; subcutaneous adipose tissue; ; abdominal fat; ; ganglionic eminence;
	Top expressed in
	Rostral migratory stream; ; ciliary body; ; genital tubercle; ; tail of embryo; ; primitive streak; ; cumulus cell; ; sciatic nerve; ; dentate gyrus of hippocampal formation granule cell; ; stroma of bone marrow; ; masseter muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; protein binding; kinase activator activity; molecular adaptor activity; proline-rich region binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; cell projection; membrane; plasma membrane; endocytic vesicle; synapse; cell junction; neuron projection; clathrin-coated pit; endomembrane system; lamellipodium; calyx of Held; presynaptic endocytic zone; nucleus; nuclear envelope; cytoplasm; endosome; cytoplasmic vesicle; recycling endosome; soma; dendritic spine; apical dendrite; intracellular vesicle; postsynaptic actin cytoskeleton; glutamatergic synapse;
Biological process	negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling; intracellular signal transduction; endocytosis; ephrin receptor signaling pathway; synaptic vesicle endocytosis; positive regulation of apoptotic process; positive regulation of phosphorylation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; membrane organization; viral process; G protein-coupled receptor signaling pathway; positive regulation of kinase activity; exocytosis; protein transport; brain development; positive regulation of growth hormone secretion; positive regulation of dendritic spine development; regulation of modification of postsynaptic actin cytoskeleton; positive regulation of caveolin-mediated endocytosis; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	6453
	16443
	ENSG00000205726
	ENSMUSG00000022957
	Q15811; Q6J334
	Q9Z0R4
NM_001001132; NM_003024; NM_001331008; NM_001331009; NM_001331010;
	NM_001331011; NM_001331012
	NM_001110275; NM_001110276; NM_010587
NP_001001132; NP_001317937; NP_001317938; NP_001317939; NP_001317940;
	NP_001317941; NP_003015
	NP_001103745; NP_001103746; NP_034717
	Wikidata
View/Edit Human	View/Edit Mouse

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.