Intersectin 2

ITSN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J3T, 1UDL, 1UE9, 1UFF, 1UHF, 3GF9, 3JZY, 4IIO
Identifiers
Aliases	ITSN2, PRO2015, SH3D1B, SH3P18, SWA, SWAP, intersectin 2
External IDs	OMIM: 604464; MGI: 1338049; HomoloGene: 22627; GeneCards: ITSN2; OMA:ITSN2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,763,962 bp
RNA expression pattern
	n/a
	Top expressed in
	zygote; ; granulocyte; ; secondary oocyte; ; iris; ; ciliary body; ; spleen; ; conjunctival fornix; ; neural layer of retina; ; retinal pigment epithelium; ; blood;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; centrosome; extracellular exosome;
Biological process	positive regulation of dendrite extension; cell differentiation; regulation of Rho protein signal transduction; endocytosis; positive regulation of signal transduction; regulation of molecular function; viral process;
	Sources:Amigo / QuickGO
Orthologs
	50618
	20403
	ENSG00000198399
	ENSMUSG00000020640
	Q9NZM3
	Q9Z0R6
	NM_147152; NM_006277; NM_019595
	NM_001198968; NM_001198969; NM_011365
NP_006268; NP_062541; NP_671494; NP_001335110; NP_001335111;
	NP_001335112; NP_001335113; NP_001335114; NP_001335115
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.