IWS1

IWS1
Identifiers
Aliases	IWS1, SUPT6H interacting protein, interacts with SUPT6H, CTD assembly factor 1
External IDs	MGI: 1920723; HomoloGene: 134421; GeneCards: IWS1; OMA:IWS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,526,886 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	32,237,381 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; mucosa of ileum; ; Achilles tendon; ; tendon of biceps brachii; ; gastrocnemius muscle; ; gonad; ; right auricle of heart; ; sural nerve; ; left ventricle; ; apex of heart;
	Top expressed in
	tail of embryo; ; hand; ; otolith organ; ; utricle; ; genital tubercle; ; superior cervical ganglion; ; zygote; ; trigeminal ganglion; ; spermatocyte; ; spermatid;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; mRNA transport; RNA splicing; regulation of histone H4 acetylation; regulation of mRNA processing; mRNA processing; regulation of mRNA export from nucleus; regulation of histone H3-K36 trimethylation; transcription, DNA-templated; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; regulation of DNA-templated transcription, elongation;
	Sources:Amigo / QuickGO
Orthologs
	55677
	73473
	ENSG00000163166
	ENSMUSG00000024384
	Q96ST2
	Q8C1D8
	NM_017969
	NM_173441
	NP_060439
	NP_775617
	Wikidata
View/Edit Human	View/Edit Mouse

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.

IWS1 is a transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.

The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival. It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.