Indoprofen

Indoprofen
Clinical data
Routes of; administration	Oral
ATC code	M01AE10 (WHO) ;
Legal status
Legal status	Withdrawn;
Pharmacokinetic data
Bioavailability	High (rapid and complete absorption)
Metabolism	Glucuronidation
Elimination half-life	2.3 hours
Excretion	Renal
Identifiers
	IUPAC name 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl); phenyl]propanoic acid;
CAS Number	31842-01-0 ;
PubChem CID	3718;
DrugBank	DB08951 ;
ChemSpider	3587 ;
UNII	CPE46ZU14N;
KEGG	D04530 ;
ChEBI	CHEBI:76162 ;
ChEMBL	ChEMBL15870 ;
CompTox Dashboard (EPA)	DTXSID5045831 ;
ECHA InfoCard	100.046.197
Chemical and physical data
Formula	C17H15NO3
Molar mass	281.311 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)C;
	InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21) ; Key:RJMIEHBSYVWVIN-UHFFFAOYSA-N ;

Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.

Clinical data

Routes of administration	Oral
ATC code	M01AE10 (WHO)
Legal status
Legal status	Withdrawn
Pharmacokinetic data
Bioavailability	High (rapid and complete absorption)
Metabolism	Glucuronidation
Elimination half-life	2.3 hours
Excretion	Renal
Identifiers
IUPAC name 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]propanoic acid
CAS Number	31842-01-0^Y
PubChem CID	3718
DrugBank	DB08951^Y
ChemSpider	3587^Y
UNII	CPE46ZU14N
KEGG	D04530^Y
ChEBI	CHEBI:76162^Y
ChEMBL	ChEMBL15870^Y
CompTox Dashboard (EPA)	DTXSID5045831
ECHA InfoCard	100.046.197
Chemical and physical data
Formula	C₁₇H₁₅NO₃
Molar mass	281.311 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)C
InChI InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)^Y Key:RJMIEHBSYVWVIN-UHFFFAOYSA-N^Y