CD278

ICOS
Identifiers
Aliases	ICOS, AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator
External IDs	OMIM: 604558; MGI: 1858745; HomoloGene: 8097; GeneCards: ICOS; OMA:ICOS - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	203,961,577 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	61,039,479 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; thymus; ; granulocyte; ; epithelium of nasopharynx; ; blood; ; testicle; ; superficial temporal artery; ; bone marrow; ; tonsil;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; blood; ; embryo; ; Paneth cell; ; spleen; ; subcutaneous adipose tissue; ; submandibular gland; ; carotid body; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane;
Biological process	T cell tolerance induction; T cell costimulation; immune response; phosphatidylinositol phosphate biosynthetic process; cell-cell adhesion; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	29851
	54167
	ENSG00000163600
	ENSMUSG00000026009
	Q9Y6W8
	Q9WVS0
	NM_012092
	NM_017480
	NP_036224
	NP_059508
	Wikidata
View/Edit Human	View/Edit Mouse

Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell.