Inotersen

Inotersen
Clinical data
Trade namesTegsedi
Other namesGSK-2998728, ISIS-420915
AHFS/Drugs.comMonograph
License data
Routes of
administration		Subcutaneous
Drug classAntisense oligonucleotides
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
UNII
KEGG
Chemical and physical data
FormulaC230H318N69O121P19S19
Molar mass7183.08 g·mol−1
3D model (JSmol)
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  • Key:KLEGMTRDCCDFJK-XDQSQZFTSA-N

Inotersen, sold under the brand name Tegsedi, is a 2'-O-(2-methoxyethyl) (2'-MOE) antisense oligonucleotide medication used for the treatment of nerve damage in adults with hereditary transthyretin-mediated amyloidosis. The sequence is TCTTG GTTACATGAA ATCCC, where C is methylated C, and the first and third section (bases 1-5 and 16–20, separated from the middle section by spaces) are MOE-modified.

The most common side effects are injection site reactions (redness, swelling, bleeding, pain, rash, and itching at the injection site), nausea, headache, tiredness, low platelet counts, and fever.

Inotersen can cause serious side effects, including low platelet counts and kidney inflammation. Because of these serious side effects, Inotersen is available in the United States only through a restricted program called the Tegsedi Risk Evaluation and Mitigation (REMS) Program.

The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.

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