IGFBP3

IGFBP3
Identifiers
Aliases	IGFBP3, BP-53, IBP3, insulin like growth factor binding protein 3
External IDs	OMIM: 146732; MGI: 96438; HomoloGene: 500; GeneCards: IGFBP3; OMA:IGFBP3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	45,921,874 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	7,163,923 bp
RNA expression pattern
	Top expressed in
	decidua; ; palpebral conjunctiva; ; cartilage tissue; ; Descending thoracic aorta; ; mucosa of urinary bladder; ; vulva; ; pericardium; ; skin of thigh; ; skin of hip; ; right lobe of liver;
	Top expressed in
	Gonadal ridge; ; gastrula; ; molar; ; vestibular sensory epithelium; ; skin of external ear; ; external carotid artery; ; efferent ductule; ; right kidney; ; lip; ; human kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; insulin-like growth factor binding; protein tyrosine phosphatase activator activity; growth factor binding; insulin-like growth factor I binding; metal ion binding; insulin-like growth factor II binding; protein binding;
Cellular component	insulin-like growth factor ternary complex; extracellular region; insulin-like growth factor binding protein complex; nucleus; extracellular space; endoplasmic reticulum lumen;
Biological process	negative regulation of protein phosphorylation; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell migration; protein phosphorylation; regulation of insulin-like growth factor receptor signaling pathway; regulation of glucose metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of myoblast differentiation; regulation of cell growth; osteoblast differentiation; positive regulation of apoptotic process; regulation of growth; negative regulation of signal transduction; type B pancreatic cell proliferation; positive regulation of MAPK cascade; negative regulation of cell population proliferation; apoptotic process; regulation of apoptotic process; post-translational protein modification; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	3486
	16009
	ENSG00000146674
	ENSMUSG00000020427
	P17936
	P47878
	NM_001013398; NM_000598
	NM_008343
	NP_000589; NP_001013416
	NP_032369
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead, IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis.