Intelectin
| Xenopus embryonic epidermal lectin | |||||||
|---|---|---|---|---|---|---|---|
Monomeric structure of XEEL-CRD with bound D-glycerol 1-phosphate. The protein is colored using a blue-red gradient from the N- to the C- terminus. Calcium ions are shown as green spheres and the coordinated water molecules are shown as red spheres. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | itln1 | ||||||
| Entrez | 398574 | ||||||
| HomoloGene | 111044 | ||||||
| PDB | 4WN0 | ||||||
| RefSeq (mRNA) | NM_001089101.1 | ||||||
| RefSeq (Prot) | NP_001082570.1 | ||||||
| UniProt | Q800K0 | ||||||
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| Human intelectin-1 | |||||||
|---|---|---|---|---|---|---|---|
Monomeric structure of human intelectin with bound allyl-beta-D-galactofuranose. The protein is colored using a blue-red gradient from the N- to the C- terminus. Calcium ions are shown as green spheres and the coordinated water molecules are shown as red spheres. | |||||||
| Identifiers | |||||||
| Symbol | ITLN1 | ||||||
| Alt. symbols | hIntL-1 | ||||||
| NCBI gene | 55600 | ||||||
| HGNC | 18259 | ||||||
| OMIM | 609873 | ||||||
| PDB | 4WMY | ||||||
| RefSeq | NP_060095 | ||||||
| UniProt | Q8WWA0 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q21.3 | ||||||
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Intelectins are lectins (carbohydrate-binding proteins) expressed in humans and other chordates. Humans express two types of intelectins encoded by ITLN1 and ITLN2 genes respectively. Several intelectins bind microbe-specific carbohydrate residues. Therefore, intelectins have been proposed to function as immune lectins. Even though intelectins contain fibrinogen-like domain found in the ficolins family of immune lectins, there is significant structural divergence. Thus, intelectins may not function through the same lectin-complement pathway. Most intelectins are still poorly characterized and they may have diverse biological roles. Human intelectin-1 (hIntL-1) has also been shown to bind lactoferrin, but the functional consequence has yet to be elucidated. Additionally, hIntL-1 is a major component of asthmatic mucus and may be involved in insulin physiology as well.