Interleukin-17 receptor
| Interleukin-17 receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | IL17R | ||||||||
| Pfam | PF08357 | ||||||||
| InterPro | IPR013568 | ||||||||
| Membranome | 8 | ||||||||
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| interleukin 17 receptor A | |||||||
|---|---|---|---|---|---|---|---|
Crystal structure of a complex of IL-17RA bound to IL-17F in a 1:2 stoichiometry. | |||||||
| Identifiers | |||||||
| Symbol | IL17RA | ||||||
| Alt. symbols | IL17R, CDw217 | ||||||
| NCBI gene | 23765 | ||||||
| HGNC | 5985 | ||||||
| OMIM | 605461 | ||||||
| RefSeq | NM_014339 | ||||||
| UniProt | Q96F46 | ||||||
| Other data | |||||||
| Locus | Chr. 22 q11.1 | ||||||
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| interleukin 17 receptor B | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL17RB | ||||||
| Alt. symbols | IL17BR | ||||||
| NCBI gene | 55540 | ||||||
| HGNC | 18015 | ||||||
| OMIM | 605458 | ||||||
| RefSeq | NM_172234 | ||||||
| UniProt | Q9NRM6 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p21.1 | ||||||
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| interleukin 17 receptor C | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL17RC | ||||||
| Alt. symbols | IL17-RL | ||||||
| NCBI gene | 84818 | ||||||
| HGNC | 18358 | ||||||
| OMIM | 610925 | ||||||
| RefSeq | NM_032732 | ||||||
| UniProt | Q8NAC3 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p25.3 | ||||||
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| Interleukin 17 receptor D | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL17RD | ||||||
| Alt. symbols | SEF, IL17RLM, FLJ35755, IL-17RD | ||||||
| NCBI gene | 54756 | ||||||
| HGNC | 17616 | ||||||
| OMIM | 606807 | ||||||
| RefSeq | NM_017563 | ||||||
| UniProt | Q8NFM7 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p21.1 | ||||||
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| interleukin 17 receptor E | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL17RE | ||||||
| Alt. symbols | FLJ23658 | ||||||
| NCBI gene | 132014 | ||||||
| HGNC | 18439 | ||||||
| RefSeq | NM_153480 | ||||||
| UniProt | Q8NFR9 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p25.3 | ||||||
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| Interleukin 17 receptor E-like | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL17REL | ||||||
| NCBI gene | 400935 | ||||||
| HGNC | 33808 | ||||||
| RefSeq | NM_001001694 | ||||||
| UniProt | Q6ZVW7 | ||||||
| Other data | |||||||
| Locus | Chr. 22 q13.33 | ||||||
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Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a member of IL-17 family ligands produced by T helper 17 cells (Th17). IL-17R family consists of 5 members: IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE. Functional IL-17R is a transmembrane receptor complex usually consisting of one IL-17RA, which is a founding member of the family, and second other family subunit, thus forming heteromeric receptor binding different ligands. IL-17A, a founding member of IL-17 ligand family binds to heteromeric IL-17RA/RC receptor complex. IL-17RB binds preferentially IL-17B and IL-17E and heteromeric IL-17RA/RE complex binds IL-17C. However, there is still unknown ligand for IL-17RD. The first identified member IL-17RA is located on human chromosome 22, whereas other subunits IL-17RB to IL-17RD are encoded within human chromosome 3.