Tennessee State Route 22
| SR 22; primary in red, secondary in yellow, business in green, alternate in blue | ||||
| Route information | ||||
| Maintained by TDOT | ||||
| Length | 172.8 mi (278.1 km) | |||
| Existed | October 1, 1923–present | |||
| Major junctions | ||||
| South end | MS 2 near Corinth, MS | |||
| North end | Kentucky Bend | |||
| Location | ||||
| Country | United States | |||
| State | Tennessee | |||
| Counties | ||||
| Highway system | ||||
| 
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State Route 22 (SR 22) is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2 (MS 2). It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.