Interstate 59
| I-59 highlighted in red | |
| Route information | |
| Length | 445.23 mi (716.53 km) | 
| Existed | 1960–present | 
| NHS | Entire route | 
| Major junctions | |
| South end | I-10 / I-12 in Slidell, LA | 
| 
 | |
| North end | I-24 near Wildwood, GA | 
| Location | |
| Country | United States | 
| States | Louisiana, Mississippi, Alabama, Georgia | 
| Highway system | |
Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans 445.23 miles (716.53 km) from a junction with I-10 and I-12 at Slidell, Louisiana, to a junction with I-24 near Wildwood, Georgia.
The highway connects the metropolitan areas of New Orleans, Louisiana; Birmingham, Alabama; and Chattanooga, Tennessee, running closely parallel to the older U.S. Route 11 (US 11) corridor for the entire distance. Approximately one-third of the route, spanning 153 miles (246 km) from Meridian, Mississippi, to Birmingham, Alabama, overlaps that of the east–west I-20.
I-59 is a four-lane freeway along its entire route, other than a short stretch from Tuscaloosa, Alabama to the southern terminus of I-459 and in Birmingham, where it widens to six lanes or more. Aside from the metropolitan areas it passes through, the I-59 corridor is mainly rural in nature, especially in Georgia.