Interstate 80 in Pennsylvania

Interstate 80 (I-80) in the US state of Pennsylvania runs for 311.12 miles (500.70 km) across the central part of the state. It is designated as the Keystone Shortway and officially as the Z.H. Confair Memorial Highway. This route was built mainly along a completely new alignment, not paralleling any earlier US Routes, as a shortcut to the tolled Pennsylvania Turnpike to the south and New York State Thruway to the north. It does not serve any major cities in Pennsylvania and is mainly a cross-state route on the Ohio–New York City corridor. Most of I-80's path across the state goes through hilly and mountainous terrain, while the route passes through relatively flat areas toward the western part of the state.

I-80 serves many smaller cities in central to northern Pennsylvania, including Sharon, Clarion, DuBois, Bellefonte, Lock Haven, Milton, Bloomsburg, Hazleton, and Stroudsburg. It also passes close but never into four larger cities: State College, Williamsport, Wilkes-Barre, and Scranton; however, a connection to State College is provided by I-99, while Williamsport is accessible via I-180, and Scranton and Wilkes-Barre are accessible via I-81, I-476 and I-380.