Isosorbide dinitrate

Isosorbide dinitrate
Clinical data
Trade names	Isordil, others
Other names	ISDN; (3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate
AHFS/Drugs.com	Monograph
MedlinePlus	a682348
License data	US DailyMed: Isosorbide dinitrate;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth
ATC code	C01DA08 (WHO) C05AE02 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	10–90%, average 25%
Metabolism	Liver
Elimination half-life	1 hour
Excretion	Kidney
Identifiers
	IUPAC name 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol;
CAS Number	87-33-2 ;
PubChem CID	6883;
DrugBank	DB00883 ;
ChemSpider	6619 ;
UNII	IA7306519N;
KEGG	D00516 ;
ChEBI	CHEBI:6061 ;
ChEMBL	ChEMBL2171310 ;
CompTox Dashboard (EPA)	DTXSID0045832 ;
ECHA InfoCard	100.001.583
Chemical and physical data
Formula	C6H8N2O8
Molar mass	236.136 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)O[C@H]1[C@H]2OC[C@H](O[N+]([O-])=O)[C@H]2OC1;
	InChI InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1 ; Key:MOYKHGMNXAOIAT-JGWLITMVSA-N ;
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Isosorbide dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent angina pectoris. It has been found to be particularly useful in heart failure due to systolic dysfunction together with hydralazine. It is taken by mouth or under the tongue.

Common side effects include headache, lightheadedness with standing, and blurred vision. Severe side effects include low blood pressure. It is unclear if use in pregnancy is safe for the baby. It should not be used together with PDE5 Inhibitors. Isosorbide dinitrate is in the nitrate family of medications and works by dilating blood vessels.

Isosorbide dinitrate was first written about in 1939. It is on the World Health Organization's List of Essential Medicines. Isosorbide dinitrate is available as a generic medication. A long-acting form exists. In 2022, isosorbide was the 119th most commonly prescribed medication in the United States, with more than 5 million prescriptions.