Jumping translocation breakpoint

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Jumping translocation breakpoint protein (JTB)
Jumping translocation breakpoint protein (JTB)
Identifiers
Symbol	JTB
Pfam	PF05439
InterPro	IPR008657
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

JTB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KJX
Identifiers
Aliases	JTB, HHSPC222, PAR, hJT, jumping translocation breakpoint
External IDs	OMIM: 604671; MGI: 1346082; HomoloGene: 4870; GeneCards: JTB; OMA:JTB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,977,674 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,143,145 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of ileum; ; mucosa of sigmoid colon; ; tibia; ; pancreatic ductal cell; ; body of pancreas; ; skin of thigh; ; pituitary gland; ; anterior pituitary; ; Epithelium of choroid plexus;
	Top expressed in
	parotid gland; ; Ileal epithelium; ; saccule; ; seminal vesicula; ; Paneth cell; ; lacrimal gland; ; epithelium of lens; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase binding;
Cellular component	cytoplasm; integral component of membrane; centrosome; spindle; midbody; integral component of plasma membrane; cytoskeleton; membrane; mitochondrion; microtubule organizing center;
Biological process	apoptotic process; cell division; cell cycle; apoptotic mitochondrial changes; regulation of cell population proliferation; positive regulation of protein kinase activity; mitotic cell cycle; mitotic cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	10899
	23922
	ENSG00000143543
	ENSMUSG00000027937
	O76095
	O88824
	NM_006694
	NM_206924
	NP_006685
	NP_996807
	Wikidata
View/Edit Human	View/Edit Mouse

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene. It is an orphan receptor with unknown function.

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC). JTB has also been implicated in prostatic carcinomas.