JWH-251

JWH-251
Names
	Preferred IUPAC name 2-(2-Methylphenyl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one
Identifiers
CAS Number	864445-39-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL364820 ;
ChemSpider	9791472 ;
PubChem CID	11616723;
UNII	55H9NDH32M ;
CompTox Dashboard (EPA)	DTXSID80235555 ;
	InChI InChI=1S/C22H25NO/c1-3-4-9-14-23-16-20(19-12-7-8-13-21(19)23)22(24)15-18-11-6-5-10-17(18)2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3 Key: YBIPNGRKUAVSBG-UHFFFAOYSA-N ;
	SMILES O=C(c2c1ccccc1n(c2)CCCCC)Cc3ccccc3C;
Properties
Chemical formula	C22H25NO
Molar mass	319.448 g·mol−1
Pharmacology
Legal status	BR: Class F2 (Prohibited psychotropics); DE: Anlage II; US: Schedule I;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

JWH-251 (1-pentyl-3-(2-methylphenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about five times selectivity for CB₁ with a K_i of 29 nM and 146 nM at CB₂. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-bromo compound JWH-249, JWH-251 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.

In the United States, all CB₁ receptor agonists of the 3-phenylacetylindole class such as JWH-251 are Schedule I Controlled Substances.