JWH-373

JWH-373
Legal status
Legal status
Identifiers
  • [5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC30H33NO
Molar mass423.600 g·mol−1
3D model (JSmol)
  • O=C(C=1C=C(C=2C=CC(=CC2)CCCC)N(C1)CCCCC)C3=CC=CC=4C=CC=CC43
  • InChI=1S/C30H33NO/c1-3-5-11-20-31-22-25(21-29(31)27-18-10-8-15-24(27)13-6-4-2)30(32)28-19-12-16-23-14-7-9-17-26(23)28/h7-10,12,14-19,21-22H,3-6,11,13,20H2,1-2H3 Y
  • Key:LDGBUSJKRUNXPK-UHFFFAOYSA-N Y

JWH-373 ([5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB1 (Ki = 60 ± 3nM) and CB2 (Ki = 69 ± 2nM) receptors, with a slight selectivity for the former. JWH-373 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.

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