James Murray Irwin
| Born | 13 February 1858 Manorcunningham, County Donegal, Ireland |
|---|---|
| Died | 7 November 1938 (aged 80) Bideford, Devon, England |
| Allegiance | United Kingdom |
| Branch | British Army |
| Years of service | 1881–1919 |
| Rank | Major General |
| Unit | Royal Army Medical Corps |
| Awards | Knight Commander of the Order of St Michael and St George, Companion of the Order of the Bath. |
Major-General Sir James Murray Irwin KCMG CB (13 February 1858 – 7 November 1938) was a British physician. He served as a British Army doctor in Sudan, the Second Boer War and World War I.