Spondylocostal dysostosis
| Jarcho-Levin Syndrome | |
|---|---|
| Radiograph depicting typical skeletal features of Jarcho-Levin syndrome, subtype spondylothoracic dysplasia. Note fanlike configuration of the ribs, with extensive posterior fusion, along with multiple vertebral segmentation defects. | |
| Specialty | Medical genetics |
Spondylocostal dysostosis, also known as Jarcho-Levin syndrome (JLS), is a rare, heritable axial skeleton growth disorder. It is characterized by widespread and sometimes severe malformations of the vertebral column and ribs, shortened thorax, and moderate to severe scoliosis and kyphosis. Individuals with Jarcho-Levin typically appear to have a short trunk and neck, with arms appearing relatively long in comparison, and a slightly protuberant abdomen. Severely affected individuals may have life-threatening pulmonary complications due to deformities of the thorax. The syndrome was first described by Saul Jarcho and Paul M. Levin at Johns Hopkins University in 1938.