José Santos Guardiola
José Santos Guardiola Bustillo  | |
|---|---|
| President of Honduras | |
| In office 17 February 1856 – 11 January 1862  | |
| Vice President | José María Lazo Guillén Victoriano Castellanos  | 
| Preceded by | Francisco de Aguilar | 
| Succeeded by | José María Medina | 
| Personal details | |
| Born | 11 January 1816 Tegucigalpa, Honduras  | 
| Died | 11 January 1862 (aged 45) Comayagua, Honduras  | 
| Political party | National Party of Honduras | 
| Spouse | Ana Arbizú y Flores | 
José Santos Guardiola Bustillo (1 November 1816 – 11 January 1862) was a two-term President of Honduras. He is the only President of Honduras to be assassinated while in office in a crime committed by his personal guard.