Kalirin

KALRN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WFW
Identifiers
Aliases	KALRN, ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin, RhoGEF kinase, kalirin RhoGEF kinase
External IDs	OMIM: 604605; MGI: 2685385; HomoloGene: 57160; GeneCards: KALRN; OMA:KALRN - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	124,726,325 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	34,393,902 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; frontal pole; ; Brodmann area 10; ; ascending aorta; ; Descending thoracic aorta; ; right coronary artery; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; right frontal lobe; ; sural nerve;
	Top expressed in
	cingulate gyrus; ; primary motor cortex; ; prefrontal cortex; ; CA3 field; ; dentate gyrus; ; visual cortex; ; primary visual cortex; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; guanyl-nucleotide exchange factor activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; GTPase activator activity;
Cellular component	cytoplasm; actin cytoskeleton; extracellular exosome; cytoskeleton; nucleoplasm; cytosol; postsynaptic density;
Biological process	intracellular signal transduction; phosphorylation; ephrin receptor signaling pathway; nervous system development; protein phosphorylation; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; vesicle-mediated transport; signal transduction; positive regulation of dendritic spine morphogenesis; behavioral response to cocaine; behavioral fear response; social behavior; regulation of protein localization to plasma membrane; positive regulation of GTPase activity; regulation of synaptic transmission, glutamatergic; memory; positive regulation of dendritic spine development; Rho protein signal transduction; neuromuscular junction development; lactation; adult locomotory behavior; response to mechanical stimulus; smooth muscle cell migration; Maternal behavior; habituation; regulation of neuronal synaptic plasticity; smooth muscle cell proliferation; negative regulation of growth hormone secretion; maternal process involved in parturition; behavioral response to formalin induced pain; positive regulation of long-term synaptic potentiation; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8997
	545156
	ENSG00000160145
	ENSMUSG00000061751
	O60229
	A2CG49
NM_001024660; NM_003947; NM_007064; NM_001322988; NM_001322989;
	NM_001322990; NM_001322991; NM_001322992; NM_001322993; NM_001322994; NM_001322995; NM_001322996; NM_001322997; NM_001322998; NM_001322999; NM_001323000; NM_001323001; NM_001388412; NM_001388413; NM_001388414; NM_001388415; NM_001388416; NM_001388417; NM_001388418; NM_001388419
	NM_001164268; NM_177357
NP_001019831; NP_001309917; NP_001309918; NP_001309919; NP_001309920;
	NP_001309921; NP_001309922; NP_001309923; NP_001309924; NP_001309925; NP_001309926; NP_001309927; NP_001309928; NP_001309929; NP_001309930; NP_003938; NP_008995
	NP_001157740; NP_796331
	Wikidata
View/Edit Human	View/Edit Mouse

Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1. Is also known to play an important role in nerve growth and axonal development.

Kalirin is a member of the Dbl family of proteins and is a Rho guanine nucleotide exchange factor.

It is named after the multiple-handed Hindu goddess Kali for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named TRIO. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain.