KARS (gene)

KARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BJU, 4DPG, 4YCU, 4YCW
Identifiers
Aliases	KARS1, KARS2, CMTRIB, lysyl-tRNA synthetase 1, KRS, Lysyl-tRNA synthetase, KARS, DFNB89, LEPID, DEAPLE
External IDs	OMIM: 601421; MGI: 1934754; HomoloGene: 4053; GeneCards: KARS1; OMA:KARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,648,643 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,737,955 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; parietal pleura; ; visceral pleura; ; epithelium of nasopharynx; ; skin of hip; ; parotid gland; ; endothelial cell; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle; ; deltoid muscle;
	Top expressed in
	primitive streak; ; epiblast; ; yolk sac; ; otic vesicle; ; ventricular zone; ; tail of embryo; ; otic placode; ; embryo; ; embryo; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; amino acid binding; tRNA binding; lysine-tRNA ligase activity; ligase activity; protein binding; nucleic acid binding; ATP binding; ATP adenylyltransferase activity; protein homodimerization activity; transferase activity; identical protein binding;
Cellular component	membrane; plasma membrane; extracellular region; mitochondrial matrix; mitochondrion; extracellular space; aminoacyl-tRNA synthetase multienzyme complex; nucleus; cytoplasm; cytosol;
Biological process	protein biosynthesis; tRNA processing; tRNA aminoacylation for protein translation; lysyl-tRNA aminoacylation; viral process; basophil activation involved in immune response; negative regulation of cell population proliferation; positive regulation of macrophage chemotaxis; tumor necrosis factor-mediated signaling pathway; positive regulation of macrophage activation; positive regulation of transcription, DNA-templated; ERK1 and ERK2 cascade; positive regulation of ERK1 and ERK2 cascade; positive regulation of cytokine production involved in inflammatory response; positive regulation of p38MAPK cascade; positive regulation of metallopeptidase activity; diadenosine tetraphosphate biosynthetic process; response to X-ray;
	Sources:Amigo / QuickGO
Orthologs
	3735
	85305
	ENSG00000065427
	ENSMUSG00000031948
	Q15046
	Q99MN1
	NM_005548; NM_001130089; NM_001378148
	NM_001130868; NM_001286384; NM_053092; NM_001363429; NM_001363430
	NP_001123561; NP_005539; NP_001365077
	NP_001124340; NP_001273313; NP_444322; NP_001350358; NP_001350359
	Wikidata
View/Edit Human	View/Edit Mouse

Lysyl-tRNA synthetase is an enzyme that in humans is encoded by the KARS gene.