KAT5

KAT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKO, 2OU2, 4QQG
Identifiers
Aliases	KAT5, ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2, lysine acetyltransferase 5, NEDFASB
External IDs	OMIM: 601409; MGI: 1932051; HomoloGene: 100661; GeneCards: KAT5; OMA:KAT5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,719,604 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,660,265 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; body of uterus; ; gastric mucosa; ; right hemisphere of cerebellum; ; muscle layer of sigmoid colon; ; left lobe of thyroid gland; ; left uterine tube; ; popliteal artery; ; tibial arteries;
	Top expressed in
	neural layer of retina; ; spermatocyte; ; granulocyte; ; yolk sac; ; interventricular septum; ; genital tubercle; ; hand; ; ventricular zone; ; medial vestibular nucleus; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; transcription coactivator activity; metal ion binding; histone acetyltransferase activity; protein binding; androgen receptor binding; acetyltransferase activity; acyltransferase activity; H4 histone acetyltransferase activity; histone binding;
Cellular component	cytoplasm; transcription regulator complex; Piccolo NuA4 histone acetyltransferase complex; nucleoplasm; nucleolus; perinuclear region of cytoplasm; nucleus; Swr1 complex; NuA4 histone acetyltransferase complex; histone acetyltransferase complex;
Biological process	response to ionizing radiation; androgen receptor signaling pathway; regulation of transcription, DNA-templated; cellular response to estradiol stimulus; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of protein acetylation; positive regulation of transcription, DNA-templated; regulation of growth; viral process; negative regulation of transcription, DNA-templated; double-strand break repair via nonhomologous end joining; negative regulation of interleukin-2 production; positive regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; proteasome-mediated ubiquitin-dependent protein catabolic process; DNA replication; DNA double-strand break processing; beta-catenin-TCF complex assembly; double-strand break repair; histone acetylation; chromatin organization; histone H4 acetylation; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	10524
	81601
	ENSG00000172977
	ENSMUSG00000024926
	Q92993
	Q8CHK4
	NM_001206833; NM_006388; NM_182709; NM_182710
NM_001199247; NM_001199248; NM_001199249; NM_178637; NM_001362370;
	NM_001362371; NM_001362372
	NP_001193762; NP_006379; NP_874368; NP_874369
NP_001186176; NP_001186177; NP_001186178; NP_848752; NP_001349299;
	NP_001349300; NP_001349301
	Wikidata
View/Edit Human	View/Edit Mouse

Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene. It is also commonly identified as TIP60.

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.