KCNA4

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Potassium channel Kv1.4 tandem inactivation domain
Potassium channel Kv1.4 tandem inactivation domain
	solution structure of the tandem inactivation domain (residues 1-75) of potassium channel rck4 (kv1.4)
Identifiers
Symbol	K_channel_TID
Pfam	PF07941
InterPro	IPR012897
SCOP2	1kn7 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

KCNA4
Identifiers
Aliases	KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2, potassium voltage-gated channel subfamily A member 4, MCIDDS
External IDs	OMIM: 176266; MGI: 96661; HomoloGene: 20514; GeneCards: KCNA4; OMA:KCNA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	30,017,030 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	107,128,847 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; secondary oocyte; ; caudate nucleus; ; left adrenal cortex; ; putamen; ; prefrontal cortex; ; right adrenal gland; ; right adrenal cortex; ; ventricular zone; ; paraflocculus of cerebellum;
	Top expressed in
	nucleus accumbens; ; lumbar spinal ganglion; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; olfactory tubercle; ; substantia nigra; ; globus pallidus; ; mammillary body; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; potassium ion binding; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity;
Cellular component	integral component of membrane; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; axon; integral component of plasma membrane; dendritic spine;
Biological process	regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	3739
	16492
	ENSG00000182255
	ENSMUSG00000042604
	P22459
	Q61423
	NM_002233
	NM_021275
	NP_002224
	NP_067250
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily A member 4 also known as K_v1.4 is a protein that in humans is encoded by the KCNA4 gene. It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.