KCNE1

KCNE1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2K21
Identifiers
Aliases	KCNE1, ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, potassium voltage-gated channel subfamily E regulatory subunit 1
External IDs	OMIM: 176261; GeneCards: KCNE1; OMA:KCNE1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	34,512,214 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; olfactory zone of nasal mucosa; ; granulocyte; ; spleen; ; right lung; ; upper lobe of left lung; ; apex of heart; ; bone marrow cells; ; fallopian tube;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; delayed rectifier potassium channel activity; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated ion channel activity; telethonin binding; potassium channel regulator activity; protein binding; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity; transmembrane transporter binding;
Cellular component	membrane; integral component of membrane; voltage-gated potassium channel complex; plasma membrane; cell surface; Z discdkac; apical plasma membrane; membrane raft; lysosome;
Biological process	regulation of ion transmembrane transport; protein O-linked glycosylation; ventricular cardiac muscle cell action potential; cardiac muscle cell action potential involved in contraction; ion transport; hearing; potassium ion transport; membrane repolarization; negative regulation of protein targeting to membrane; membrane repolarization during action potential; regulation of delayed rectifier potassium channel activity; cardiac conduction; potassium ion transmembrane transport; positive regulation of potassium ion transmembrane transport; protein N-linked glycosylation; membrane repolarization during cardiac muscle cell action potential; regulation of heart rate by cardiac conduction; regulation of potassium ion transmembrane transport; negative regulation of delayed rectifier potassium channel activity; cellular response to cAMP; regulation of ventricular cardiac muscle cell membrane repolarization; membrane repolarization during ventricular cardiac muscle cell action potential; transport; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3753
	n/a
	ENSG00000180509
	n/a
	P15382; Q6FHJ6
	n/a
NM_000219; NM_001127668; NM_001127669; NM_001127670; NM_001270402;
	NM_001270403; NM_001270404; NM_001270405
	n/a
NP_000210; NP_001121140; NP_001121141; NP_001121142; NP_001257331;
	NP_001257332; NP_001257333; NP_001257334; NP_000210.2
	n/a
	Wikidata
View/Edit Human

Potassium voltage-gated channel subfamily E member 1 is a protein that in humans is encoded by the KCNE1 gene.

Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

KCNE1 is one of five members of the KCNE family of Kv channel ancillary or β subunits. It is also known as minK (minimal potassium channel subunit).