KCNE2

KCNE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M0Q
Identifiers
Aliases	KCNE2, ATFB4, LQT5, LQT6, MIRP1, potassium voltage-gated channel subfamily E regulatory subunit 2
External IDs	OMIM: 603796; MGI: 1891123; HomoloGene: 71688; GeneCards: KCNE2; OMA:KCNE2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	34,371,381 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	92,095,017 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; pylorus; ; cardia; ; testicle; ; fundus; ; gonad; ; Descending thoracic aorta; ; duodenum; ; tibial arteries; ; right coronary artery;
	Top expressed in
	Epithelium of choroid plexus; ; epithelium of stomach; ; vestibular membrane of cochlear duct; ; mucous cell of stomach; ; neural layer of retina; ; pyloric antrum; ; right lung lobe; ; epithelium of lens; ; choroid plexus of lateral ventricle; ; myocardium of atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; protein homodimerization activity; transmembrane transporter binding; delayed rectifier potassium channel activity; voltage-gated ion channel activity; potassium channel regulator activity; protein binding; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity; inward rectifier potassium channel activity;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane; lysosome; endoplasmic reticulum; Golgi apparatus; cell surface;
Biological process	negative regulation of voltage-gated potassium channel activity; tongue development; regulation of inward rectifier potassium channel activity; positive regulation of voltage-gated calcium channel activity; regulation of ion transmembrane transport; ventricular cardiac muscle cell action potential; ageing; cardiac muscle cell action potential involved in contraction; ion transport; potassium ion transport; membrane repolarization; membrane repolarization during action potential; regulation of delayed rectifier potassium channel activity; cardiac conduction; potassium ion transmembrane transport; regulation of membrane repolarization; positive regulation of proteasomal protein catabolic process; regulation of heart rate by cardiac conduction; regulation of potassium ion transmembrane transport; regulation of cyclic nucleotide-gated ion channel activity; negative regulation of delayed rectifier potassium channel activity; regulation of ventricular cardiac muscle cell membrane repolarization; membrane repolarization during ventricular cardiac muscle cell action potential; transport; potassium ion export across plasma membrane; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9992
	246133
	ENSG00000159197
	ENSMUSG00000039672
	Q9Y6J6
	Q9D808
	NM_172201; NM_005136
	NM_134110; NM_001358372
	NP_751951
	NP_598871; NP_001345301
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily E member 2 (KCNE2), also known as MinK-related peptide 1 (MiRP1), is a protein that in humans is encoded by the KCNE2 gene on chromosome 21. MiRP1 is a voltage-gated potassium channel accessory subunit (beta subunit) associated with Long QT syndrome. It is ubiquitously expressed in many tissues and cell types. Because of this and its ability to regulate multiple different ion channels, KCNE2 exerts considerable influence on a number of cell types and tissues. Human KCNE2 is a member of the five-strong family of human KCNE genes. KCNE proteins contain a single membrane-spanning region, extracellular N-terminal and intracellular C-terminal. KCNE proteins have been widely studied for their roles in the heart and in genetic predisposition to inherited cardiac arrhythmias. The KCNE2 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. More recently, roles for KCNE proteins in a variety of non-cardiac tissues have also been explored.