KCNJ6

KCNJ6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E4F, 3AGW, 3AT8, 3AT9, 3ATA, 3ATB, 3ATD, 3ATE, 3ATF, 3AUW, 3SYA, 3SYC, 3SYO, 3SYP, 3SYQ, 3VSQ, 4KFM
Identifiers
Aliases	KCNJ6, BIR1, GIRK-2, GIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, hiGIRK2, KPLBS, potassium voltage-gated channel subfamily J member 6, potassium inwardly rectifying channel subfamily J member 6
External IDs	OMIM: 600877; MGI: 104781; HomoloGene: 1688; GeneCards: KCNJ6; OMA:KCNJ6 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	38,121,345 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	94,798,560 bp
RNA expression pattern
	Top expressed in
	pars reticulata; ; pars compacta; ; middle temporal gyrus; ; Brodmann area 23; ; frontal pole; ; postcentral gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; entorhinal cortex; ; cerebellar vermis;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; primary visual cortex; ; superior frontal gyrus; ; pretectal area; ; gastrula; ; blastocyst; ; CA3 field; ; lumbar spinal ganglion; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G-protein activated inward rectifier potassium channel activity; protein binding; inward rectifier potassium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; Golgi apparatus; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3763
	16522
	ENSG00000157542
	ENSMUSG00000043301
	P48051
	P48542
	NM_002240
	NM_001025584; NM_001025585; NM_001025590; NM_010606
	NP_002231
	NP_001020755; NP_001020756; NP_001020761; NP_034736
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome (KPLBS).