KCNK18

KCNK18
Identifiers
Aliases	KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDs	OMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	117,210,299 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	59,225,806 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; Hypothalamus; ; renal cortex; ; anterior cingulate cortex;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-activated potassium channel activity; outward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; cellular response to pH; ion transport; potassium ion transmembrane transport; stabilization of membrane potential; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	338567
	332396
	ENSG00000186795
	ENSMUSG00000040901
	Q7Z418
	Q6VV64
	NM_181840
	NM_207261
	NP_862823
	NP_997144
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K_2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K_2P18.1 is a potassium channel containing two pore-forming P domains.

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.