SK3

KCNN3
Identifiers
Aliases	KCNN3, KCa2.3, SK3, SKCA3, hSK3, potassium calcium-activated channel subfamily N member 3, ZLS3
External IDs	OMIM: 602983; MGI: 2153183; HomoloGene: 20516; GeneCards: KCNN3; OMA:KCNN3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,870,281 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,582,439 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; pars reticulata; ; internal globus pallidus; ; pars compacta; ; dorsal motor nucleus of vagus nerve; ; ventral tegmental area; ; superior vestibular nucleus; ; entorhinal cortex; ; tendon of biceps brachii; ; lateral nuclear group of thalamus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; ascending aorta; ; primary visual cortex; ; aortic valve; ; ventricular zone; ; ganglionic eminence; ; embryo; ; supraoptic nucleus; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	small conductance calcium-activated potassium channel activity; calcium-activated potassium channel activity; calmodulin binding;
Cellular component	integral component of membrane; soma; plasma membrane; membrane; neuron projection;
Biological process	potassium ion transport; ion transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3782
	140493
	ENSG00000143603
	ENSMUSG00000000794
	Q9UGI6
	P58391
	NM_170782; NM_001204087; NM_002249; NM_001365837; NM_001365838
	NM_080466
	NP_001191016; NP_002240; NP_740752; NP_001352766; NP_001352767
	NP_536714
	Wikidata
View/Edit Human	View/Edit Mouse

SK3 (small conductance calcium-activated potassium channel 3) also known as K_Ca2.3 is a protein that in humans is encoded by the KCNN3 gene.

SK3 is a small-conductance calcium-activated potassium channel partly responsible for the calcium-dependent after hyperpolarisation current (I_AHP). It belongs to a family of channels known as small-conductance potassium channels, which consists of three members – SK1, SK2 and SK3 (encoded by the KCNN1, 2 and 3 genes respectively), which share a 60-70% sequence identity. These channels have acquired a number of alternative names, however a NC-IUPHAR has recently achieved consensus on the best names, K_Ca2.1 (SK1), K_Ca2.2 (SK2) and K_Ca2.3 (SK3). Small conductance channels are responsible for the medium and possibly the slow components of the I_AHP.