KCNS3

KCNS3
Identifiers
Aliases	KCNS3, KV9.3, potassium voltage-gated channel modifier subfamily S member 3
External IDs	OMIM: 603888; MGI: 1098804; HomoloGene: 20518; GeneCards: KCNS3; OMA:KCNS3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	18,361,616 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	11,201,057 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; visceral pleura; ; Skeletal muscle tissue of biceps brachii; ; retinal pigment epithelium; ; hair follicle; ; muscle of thigh; ; palpebral conjunctiva; ; gastrocnemius muscle; ; upper lobe of left lung;
	Top expressed in
	lumbar spinal ganglion; ; morula; ; olfactory epithelium; ; embryo; ; embryo; ; blastocyst; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; white adipose tissue; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity; ion channel activity; potassium channel regulator activity; voltage-gated potassium channel activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; voltage-gated potassium channel complex; plasma membrane; cytosol;
Biological process	regulation of insulin secretion; regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	3790
	238076
	ENSG00000170745
	ENSMUSG00000043673
	Q9BQ31
	Q8BQZ8
	NM_001282428; NM_002252
	NM_001168564; NM_173417
	NP_001269357; NP_002243
	NP_001162036; NP_775593
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene. KCNS3 gene belongs to the S subfamily of the potassium channel family. It is highly expressed in pulmonary artery myocytes, placenta, and parvalbumin-containing GABA neurons in brain cortex. In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness, whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia.