KDM2A

KDM2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YU1, 2YU2, 4BBQ
Identifiers
Aliases	KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA, lysine demethylase 2A
External IDs	OMIM: 605657; MGI: 1354736; HomoloGene: 56564; GeneCards: KDM2A; OMA:KDM2A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,258,082 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,448,313 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; germinal epithelium; ; tibia; ; buccal mucosa cell; ; sural nerve; ; nipple; ; visceral pleura; ; parietal pleura; ; mucosa of paranasal sinus; ; bone marrow cells;
	Top expressed in
	hand; ; genital tubercle; ; tail of embryo; ; aortic valve; ; ascending aorta; ; mesenteric lymph nodes; ; granulocyte; ; neural layer of retina; ; lumbar subsegment of spinal cord; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; oxidoreductase activity; zinc ion binding; dioxygenase activity; metal ion binding; histone demethylase activity; protein binding; histone H3-methyl-lysine-36 demethylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	double-strand break repair via nonhomologous end joining; regulation of transcription, DNA-templated; histone H3-K36 demethylation; transcription, DNA-templated; chromatin organization; regulation of transcription by RNA polymerase II; negative regulation of transcription by competitive promoter binding; circadian regulation of gene expression; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	22992
	225876
	ENSG00000173120
	ENSMUSG00000054611
	Q9Y2K7
	P59997
	NM_001256405; NM_012308
	NM_001001984
	NP_001243334; NP_036440
	NP_001001984
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in humans is encoded by the KDM2A gene. KDM2A is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.